Tittel: Forsker
Telefon:
Mobil:    +47 97 79 41 71
Faks:     + 47 77 64 61 00
E-post: mahmud.khan@uit.no
mthkhan2002@yahoo.com

My self

Throughout my research career I have been enjoying working in diverse sub-fields of Drug Discovery from in vivo pharmacology to in silico or computational biology (some people prefer the word – “Bioinformatics”) and drug design.
I have received my PhD on Molecular and Structural Biology from University of Tromsø, Norway, during 2009. My PhD thesis was concerning discovery of novel inhibitors of Thermolysin, a model zinc proteinase, using both the experimental and computational approaches.

Before coming to Tromsø I was working as a “Researcher” at Department of Molecular Biology and Biochemistry at University of Ferrara, Italy and I was working on the projects “Discovery of Potential Molecules against Cancer and Thalassemia” and “Interactions of Transcription Factors and HIV-1 TAR RNA”. Earlier I was working as “Research fellow” in different institutions in Bangladesh and Pakistan for several years (from 1993 to onwards).

During 2009 I also worked as “Visiting Researcher” at Faculty of Pharmacy, Gazi University, Ankara, Turkey. In UiTø besides my own research works I was also responsible for teaching in Pharmacology for Master students as well as I supervised and co-supervised couple of students for their thesis and project works.

Research interests

Here at GenØk my research responsibilities are to take care of Transcriptomics projects, where we are interested to study the effects of genetically modified (GM) foods, like BT-maize, RR-soy, etc., on the transcriptome of model organisms like Daphnia magna, etc., and their bioinformatic analyses from different perceptions.

My CV

Some of my recent and selected papers (last 5 years)

(A) Patent:
[1] Rahman, A.U.; Choudhary, M.I.; Shah, S.A.A.; Khan, M.T.H. New tyrosinase enzyme inhibitors from fungal hydroxylation of Tibolone. US Patent. Application no. 11944476, 2007 [USA].

(B) Published or accepted for publications:
[2] Lampronti I, Khan MTH, Bianchi N, Ather A, Borgatti M, Vizziello L, Fabbri E, Gambari R. Bangladeshi Medicinal Plant Extracts Inhibiting Molecular Interactions between NF-kappa  and Target DNA Sequences. Medicinal Chemistry, 2005; 1(4):327-33 [The Netherlands].
[3] Lambertini E, Lampronti I, Penolazzi L, Khan MTH, Ather A, Giorgi G, Gambari R, Piva R. Expression of Estrogen Receptor  Receptor Gene in Breast Cancer Cells Treated with Transcription factor Decoy is modulated by Bangladeshi Plant Extracts. Oncology Research and Anticancer Drug Design, 2005;15(2):69-79 [U.S.A.]
[4] Choudhary MI, Sultan S, Khan MTH, Rahman AU. Microbial Transformation of 17-Ethynyl and 17-Ethyl steroids: Tyrosinase Inhibition of 17-Ethynyl and 17-Ethyl Analogues. Steroid, 2005 Nov;70(12):798-802. [United Kingdom]
[5] Khan SB, Khan MTH, Haq AU, Afza N, Malik A, Choudhary MI, Ahmed Z. Long Chain Tyrosinase Inhibitory Esters from the Whole Plant of the Amberboa ramose Jafri. Chemical and Pharmaceutical Bulletin, 2005, 53(1): 86-89 [Japan].
[6] Khan KM, Maharvi GM, Khan MTH, Choudhary MI, Rahman AU. Synthesis and Tyrosinase Inhibitory Studies of Vigra-II Series of compounds. Helvetica Chimica Acta, 2005 [Switzerland]
[7] Khan MTH, Choudhary MI, Khan KM, Rani M, Rahman AU. Structure-Activity Relationships of Tyrosinase Inhibitory Combinatorial Library of 2,5-Disubstituted-1,3,4-Oxadiazole Analogues. Bioorganic and Medicinal Chemistry, 2005, 13(10):3385-95 [U.S.A.]
[8] Lampronti I, Bianchi N, Borgatti M, Fabbri M, Vizziello L, Khan MTH, Ather A, Brezena D, Tahir MM, Gambari R. Effects of Vanadium Complexes on Cell Growth of Human Leukemia Cells and on Protein-DNA Interactions. Oncology Report, 2005 [USA]
[9] Thompson K, Ather A, Khan MTH. Antiviral activities of three Bangladeshi medicinal plant extracts against herpes simplex virus. Minerva Biotechnologica, 2005, 17(3), 193-199 [Italy]
[10] Khan MTH, Ather A, Thompson KD, Gambari R. Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral Research 2005, 67:107-119 [Invited Review, 2005 TOP-Hot paper of Antiviral Research] [USA]
[11] Khan KM, Maharvi GM, Khan MTH, Jabbar Shaikh A, Perveen S, Begum S, Choudhary MI. Tetraketones: a new class of tyrosinase inhibitors. Bioorganic and Medicinal Chemistry. 2006;14(2):344-51. [USA]
[12] Khan KM, Saify ZS, Khan MTH, Butt N, Maharvi GM, Perveen S, Ambreen N, Choudhary MI, Atta-Ur-Rahman, Supuran CT. Tyrosinase inhibition: conformational analysis based studies on molecular dynamics calculations of bipiperidine based inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 2005; 20(4):401-7. [The Netherlands]
[13] Khan MTH, Choudhary MI, Atta-ur-Rahman, Mamedova RP, Agzamova MA, Sultankhodzhaev MN, Isaev MI. Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships. Bioorganic and Medicinal Chemistry 2006;14(17):6085-8. [USA]
[14] Khan KM, Mughal UR, Khan MTH, Zia-Ullah, Perveen S, Choudhary MI. Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships. Bioorganic and Medicinal Chemistry 2006; 14(17):6027-33. [USA]
[15] Azhar-Ul-Haq, Malik A, Khan MTH, Anwar-Ul-Haq, Khan SB, Ahmad A, Choudhary MI. Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship. Phytomedicine. 2006 Mar;13(4):255-60. [The Netherlands]
[16] Khan KM, Maharvi GM, Khan MTH, Jabbar Shaikh A, Perveen S, Begum S, Choudhary MI. Tetraketones: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2006 Jan 15;14(2):344-51. [The Netherlands]
[17] Khan, M.T.H. and Sylte, S. Predictive QSAR Modeling for the Successful Predictions of the ADMET Properties of Candidate Drug Molecules. Current Drug Discovery Technologies, 4(3), 2007, 141-149. [The Netherlands]
[18] Devkota KP, Khan MTH, Ranjit R, Lannang AM, Samreen, Choudhary MI. Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007 Apr;21(4):321-7. [United Kingdom]
[19] Previati M, Corbacella E, Astolfi L, Catozzi M, Khan MTH, Lampronti I, Gambari R, Capitani S, Martini A. Ethanolic extract from Hemidesmus indicus (Linn) displays otoprotectant activities on organotypic cultures without interfering on gentamicin uptake. J Chem Neuroanat. 2007 Nov;34(3-4):128-33. [The Netherlands]
[20] Khan, M.T.H., Yimingjiang, W., Sylte, I. Molecular Recognition of Thermolysin and Homologous Zn-Metalloproteinases. Minerva Biotechnologica, 2007, 19(4):139-150 (Invited review) [Italy]
[21] Lampronti I, Khan MTH, Borgatti M, Bianchi N, Gambari R. Inhibitory Effects of Medicinal Plant Extracts on Interactions between Transcription Factors and Target DNA Sequences. Evidence Based Complement Alternative Med. 2008 Sep;5(3):303-312 [UK].
[22] Khan MTH, Sylte I. Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays. Journal of Medicinal Chemistry, 2009, Jan 8;52(1):48-61
[23] Khan, M.T.H. and Sylte, I. Determinants for psychrophilic and thermophilic features of metallopeptidases of the M4 family. In Silico Biology 9, 0010 (2009) [Germany].
[24] Khan MTH, Orhan I, Senol FS, Kartal M, Sener B, Dvorská M, Smejkal K, Slapetová T. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chem Biol Interact. 2009 Oct 30;181(3):383-9.
[25] Khan MTH. Molecular interactions of cholinesterases inhibitors using in silico methods: current status and future prospects. N Biotechnol. 2009 Jun;25(5):331-46.
[26] Chattopadhyay D, Sarkar MC, Chatterjee T, Sharma Dey R, Bag P, Chakraborti S, Khan MTH. Recent advancements for the evaluation of anti-viral activities of natural products. N Biotechnol. 2009 Jun;25(5):347-68.
[27] Khan, MTH; Khan, R.; Wuxiuer, Y; Arfan, M.; Ahmed, M.; Sylte, I. Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases. Bioorganic & Medicinal Chemistry 2010; 18.(12):4317-4327.
[28] Khan, S.B.; Khan, MTH; Seo, J.; Jang, E.S.; Han, H. Tyrosinase inhibitory effect of benzoic acid derivatives and their structure-activity relationship. Journal of enzyme inhibition and medicinal chemistry (Print) 2010.
[29] Kostenko, S. V.; Khan, MTH; Moens, Ugo; Sylte, Ingebrigt. The diterpenoid alkaloid Noroxoaconitine is a MAPKAP Kinase 5 (MK5/PRAK) inhibitor. Cellular and Molecular Life Sciences 2010.
[30] Khan, MTH. Predictions of the ADMET properties of candidate drug molecules utilizing different QSAR/QSPR modelling approaches. Current drug metabolism 2010,11:285-295.
[31] Casañola-Martín, G.M.; Marrero-Ponce, Y.; Khan, MTH; Khan, S.B.; Torrens, F.; Pérez-Jiménez, F.; Rescigno, A.; Abad, C. Bond-Based 2D Quadratic Fingerprints in QSAR Studies. Virtual and In Vitro Tyrosinase Inhibitory Activity Elucidation. Chemical Biology and Drug Design 2010 Dec;76(6):538-45.
[32] Marrero-Ponce, Y.; Casañola-Martín, G. M.; Khan, MTH; Torrens, F.; Rescigno, A.; Abad, C. Ligand-Based Computer-Aided Discovery of Tyrosinase Inhibitors. Applications of the TOMOCOMD-CARDD Method to the Elucidation of New Compounds.. Current pharmaceutical design 2010;16:2601-2624.
[33] Choudhary, M.I.; Shah, S.A.A.; Rahman, A.U.; Khan, S.-N.; Khan, MTH. Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones.. Steroids 2010, 75.(12):956-966.
 

(C) Submitted for publications or manuscripts:
[34] Khan, M.T.H., Dedachi, K., Matsui, T., Kurita, N., Lund, B.A., Leiros, H.-K. S., Leiros, I., Borgatti, M., Gambari, R., Sylte, I., Dipeptide Inhibitors of Thermolysin and Angiotensin I-Converting Enzyme – Experimental and Theoretical studies. Submitted.
[35] Khan, M.T.H., Yimingjiang, W., Sylte, I. Docking Calculations and Pharmacophore Modeling of Structurally Diverse set of Thermolysin Inhibitors. Under review Journal of Molecular Modeling [Germany].
[36] Khan, M.T.H., Khan, R, Yimingjiang. W., Arfan, M., Ahmed, M., Sylte I. Utilization of Chemical Arrays and Combinatorial Synthesis of Quinazolin-4(3H)-ones as a Novel Class of Thermolysin Inhibitors: Molecular Docking and Pharmacophore Modelling. Submitted to Journal of Medicinal Chemistry.
[37] Khan, M.T.H., Orhan, I., Şener, B., Sylte, I. Competitive Thermolysin Inhibitory Flavonoids: High Throughput Screening, Structure-Activity Relationships and Docking Studies. Manuscript.
[38] Khan MTH, Gambari R. Molecular Modelling Predicting the Biological Activity of Peptide Nucleic Acid (PNA) Based Therapeutic Molecules. Submitted to Minerva Biotechnologica [Italy].
[39] Ilkay Orhan, I., Khan, M.T.H., Aslan, S., Kartal, M., Şener, S., Sylte, I. Discovery of Selective and Potent Acetyl- and Butyryl-cholinesterase Inhibitors from Buxus sempervirens. Under review at Biological Research.